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Here are seven steps to curing histamine intolerance. Hi. I’m Dr. Chris Masterjohn of, and this is Chris Masterjohn Lite, where the name of the game is “Details? Shmeetails. Just tell me what works!” And today we are going to tie together all the different approaches to histamine intolerance into one seven-step path. Now, histamine intolerance, once again, is diarrhea, migraines or other headaches, nasal congestion, asthma, wheezing, low blood pressure, heart palpitations, hives, itching, flushing in response to foods that contain histamine, which is especially fermented foods, aged and preserved foods, as well as a number of others. Now, in histamine intolerance, we can look at seven ways to approach it. Way number 1: endogenous diamine oxidase, or DAO, meaning support your own production of DAO, the enzyme in your gut that is supposed to clear all the histamine from your foods. That means making sure your copper, vitamin C, and vitamin B6 status is good. I have covered how to manage your copper, vitamin C, and B6 status in previous episodes, and I’ll link to those in the description of this one. In addition, estrogen and pregnancy are important, so keep in mind that your DAO is naturally going to go up in pregnancy, and your DAO is naturally going to go down when estrogen peaks during your menstrual cycle during ovulation and in the few days before you start menstruating if you are a menstruating woman. Number 2: supplemental DAO. DAO is naturally found in some of the foods that we eat, particularly the organs of animals. I’m sure placenta is very rich; that’s why it goes up in pregnant women, but kidney, more commonly eaten as an organ meat, is a very good source of DAO. You can eat kidney. You can also eat liverwurst. For example, I like US Wellness Meats liverwurst, and that liverwurst has a significant amount of kidney ground into it. And then there are the kidney supplements. So, I do recommend Ancestral kidney supplements. Ancestral is an advertiser with this podcast. And I also recommend Seeking Health Histamine Block, which is a DAO enzyme supplement that you can use in strategic spots before the meals that contain histamine. I’ve covered how to use those supplements in more detail in a previous episode. I’ll link to it in the description. Number 3: support your methylation. Methylation is one of the principal ways that you get rid of histamine. DAO is more important in the gut, and it’s more important outside of your cells in general, whereas methylation is more important inside your cells. But if you’re thinking about cells of the immune system, such as mast cells and basophils, that are likely to release histamine and contribute to your histamine bucket, then you can reduce the amount of histamine they’re carrying around by making sure you’re supporting your methylation. I’ve covered methylation in many episodes and other resources. All of my methylation resources can be found at And I will put that link as well in the description of this episode. Number 4: mast cell control. Now, from a nutritional perspective, you want to focus on nutrients where their deficiencies have been shown to increase the burden of mast cells, and the principal deficiencies to look out for are selenium and vitamin A. So, I will put selenium and vitamin A, the episodes that I made about those nutrients, I will link to those as well in the description so you can make sure you know how to control and manage and investigate your status of those nutrients. It’s also possible that you could have an inflammatory disease increasing mast cell burden that needs to be dealt with directly with your doctor, but these nutritional approaches could be holes that you need to look for in managing your histamine balance. Number 5: the histamine in your diet. If you need to, you should cut out the worst offending foods. As a general principle, the worst offending foods are things that are fermented, aged, or preserved, especially hard or semi-hard cheese, canned anchovies, smoked fish, deli meats, but also curry, mustard, soy sauce, yeast, avocado, banana, dried fruit, dried nuts, lemon, mandarin, and pineapple are the foods that are most consistently high in histamine. You’re not really curing histamine intolerance if you need to get rid of these foods; you’re just managing it. So, the other steps that I’m listing out are ideally helping you to tolerate these foods, but to the extent that you need to take them out short-term, those would be the foods to target in the process of getting over histamine intolerance to make sure that in the moment, you feel good. If you need to cut out the foods, I would start kind of cold turkey cutting out the worst offenders. I wouldn’t get obsessive about many of the other foods that I didn’t just list there because there are many others where there’s conflicting evidence about histamine, but once you get your symptoms down to something that is manageable or ideally to zero or close to zero, then you can start reintroducing foods and test where your boundaries are to see how well you tolerate those different foods. Number 6: alcohol and other drugs that interfere with histamine clearance. As I mentioned in the previous episode, there might be some dose of alcohol that’s beneficial. It’s probably something small, on the order of a half a drink three times per week. In general though, you can expect the more alcohol you consume, the less likely you are to tolerate histamine. So either get rid of the alcohol or find whatever that sweet spot is that helps give you the best control of your symptoms. And then the many other drugs are too many to list in this episode. So I’ll link to the episode where I cover the drugs. Go back to that episode if you’re on any medications. See if any of the medications line up, and if they do, talk to your doctor about it and see whether there’s a way you can get off them or transfer to another one that doesn’t disrupt histamine metabolism. Number 7: fix the gut. Gut problems could involve poor production of the DAO enzyme because your intestinal cells are damaged, an increased mast cell burden contributing to histamine there, or microbial dysbiosis, meaning the wrong mix of bacteria are leading to the overproduction or under-degradation of histamine in the gut. And healing from any of these problems could be central to fixing your tolerance of histamine. I think this topic is way too big to address in any comprehensive fashion here, but some of the things that could be important are focusing on foods that lead to healthy stool quality, focusing on foods that don’t upset your GI tract, supplementation with gut-healing supplements, such as glutamine, or collagen, or bone broth, and in general, rest can all be super important. But again, if you have a serious problem with your gut, you may well need to work on a detailed protocol with an experienced healthcare practitioner. This episode is brought to you by Ancestral Supplements Living Collagen. Our Native American ancestors believed that eating the organs from a healthy animal would support the health of the corresponding organ of the individual. Ancestral Supplements has a nose-to-tail product line of grass-fed liver, organs, living collagen, bone marrow, and more. All in the convenience of a capsule. For more information or to buy any of their products, go to This episode is brought to you by Ample. Ample is a meal in a bottle that takes a total of two minutes to prepare, consume, and, clean up. It provides a balance of fat, protein, and carbs plus all the vitamins and minerals you need in a single meal. All from a blend of natural ingredients. It’s available in original, vegan, and keto versions portioned as either 400 or 600 calories per meal. I’m an advisor to Ample, and I use it to save time when I’m working on major projects on a tight schedule. It keeps my brain going while I power through the day, never letting food prep get in the way of my productivity. Head to and enter the promo code CHRIS15 at checkout for a 15% discount off your
first order. The audio of this episode was enhanced and post-processed by Bob Davodian of Taurean Mixing. You can find more of his work at All right, I hope you found this useful. Signing off, this is Chris Masterjohn of This has been Chris Masterjohn Lite, and I will see you in the next episode.

44 thoughts on “7 Steps to Cure Histamine Intolerance | Chris Masterjohn Lite #95

  1. I have severe nasal congestion and I can’t sleep worth a shit because of it. I switched to whole food plant based a year ago and still having problems. Any suggestions? Anything would be helpful at this point. I am literally losing my mind not sleeping

  2. hi chris i know salt is a potent antihistamine, what do you think about salting our food in order to reduce histamine, and the idea that may be its because salt help increase stomach acid and digest our food

  3. Good info; thanks! I've been working on this for awhile but haven't attacked every angle yet. However, I have seen it listed many times that bone broth is very high in histamine. And I'm wondering if taking the "wrong" probiotics over time can contribute to something like SIBO?

  4. You might want to try using meat stock (at least temporarily) instead of bone broth if you are having histamine intolerance issues. When I was dealing with this, bone broth used to knock me on my ass, but meat stock didn't. Look up the differences. Don't leave it in the fridge long either, freeze what you are not consuming.

  5. I have developed food sensitivities recently. Before I had a very good digestion. But I began to experience heartburn and digestive issues due to antidepressants I took. I don't take them anymore. But now I feel nerve pain when I eat certain foods. I now try to drink raw milk most of the time, and only eat foods that are easy to digest. I try to avoid grains and nuts. Even eggs seem to make me feel some inflammation in my joints.


  7. Interesting. A naturopath diagnosed that my copper, vitamin c and b6 levels are really low…. not a coincidence. I was vegan for 5 years and got really sick. But I thought i can only produce and absorb those nutrients if i have the gut bacteria that deals with it. So my questions is how can i get those bacteria if i can only take histamine lowering probiotics not just any probiotic… Nice video thank you though

  8. How do ppl know if this is causing it
    I just get hives flushing and insomnia and eye bags and rosacea like skin
    Dryness In body
    Sometimes stuffy nose
    Heart palp anxiety
    Urinating a lot

    So maybe I don’t have this???
    I get dermatagraphisim and hives though
    I can’t take antihistamines due to dryness

    I’m developing eating disorder

    Can I just eat these foods and see if I blush?

    I don’t get diarrhea

  9. So I clicked on this video because I am pregnant and have never had any type of skin problem in my life but this time around I have a pretty bad hives / eczema type rash that itches I thought it was Dairy then I thought it was peanut butter then I thought it was maybe eggs and I think really what it is is all the histamine High Foods combined with the high estrogen that is present in pregnancy does this sound right to you? Any advice for me??? thanks so much

  10. but doesn't bone broth have a shit ton of histamine and lead in it? seems counterintuitive. having mast cell and many other serious conditions- its hard to eat anything. i don't find pineapple to be offensive to my gut- the opposite, so i think everyone reacts to things differently. fermented foods and dried fruit will probably everyone with histamine problems to have issues tho but i think its different for fresh food.

  11. Is this intended to help deal with seasonal allergies or is this just for histamine intolerance from foods?

  12. How long does it take to clear or lower histamine to normal levels? Also, if Histamine is high, does this mean that lectins ate high in the body as well?

  13. Does anyone know if it is ok that I take St. JohnsWort? Kinda worried about getting rid of that, been taking it for so long.

  14. Thank you very much for your wonderful work. I have a question. What to think of my Internal Medicine Doctor who prescribed me a double dose of Blexten (20 mg) for my puritus, urticaria, along with Zantac (20 mg), to be taken every single day, itchy or not. I'm puzzled. I'm thinking that this protocol would do nothing towards healing the gut. What do you think about that, Dr. Chris?

  15. I know you know what you're talking about, because my symptoms are the roughest around ovulation and the week before my period.

  16. yes copper,vitamin C nad B6 also zinc are extremelly important….still staying away from high histamine foods is crucial…also histamine liberators like sunflower seeds,bananas…and many other….btw you are very well informed,thank you so much 🙂

  17. I was just reading that people with histamine intolerance also have an intolerance to collagen so I am not sure why this guy is selling that to people with this problem.

  18. I used to sneeze when i ate some vegetables and avocado i never knew why. Yesterday i bought Fermented sauerkraut and ate a fork full for the first time and maaan. I know youre supposed to feel some side effects but i started itching like crazy and ive sneezed so many times. I want to completely heal from this. I am afraid that i have bacteria Overgrowth and the probiotic in sauerkraut might feed them but i dont know anything!!! Im so confused idk what i have. I dont want to approach my doctor at all shes a Medical doctor she will give med drugs. I want to heal with natural remedies but I don’t know how to diagnose myself:(

  19. Don't you find things like kidneys and liver to be high in histamine? Even though they are a great source of b vitamins. Every time I eat chicken liver, my pulse jumps 10% the next day. And I've seen this regularly – – been keeping a food journal and waking morning pulse test for several years now

  20. I’m finding this experience so frustrating. I am currently detoxifying from mold and in the past five years, have gotten off of 15 prescription medications. But, I still can’t tolerate fermented foods, bone broth, collagen or probiotics! I eat an low histamine, AIP diet and absolutely can mot eat eggs or nuts. I want to be able to reintroduce some foods into my diet, but can’t get the beneficial bacteria because of the histamine intolerance. What should I do? For the mold, I sit in a sauna for 30 minutes 5x/week, I take 1 tsp of liposomal glutathione daily, lots of vitamin C, B complex, vitamin D, magnesium and zinc. I also take activated charcoal and bentonite clay to bind the mold. There has been improvement, but I’m still not healthy. 🙄

  21. I heard that raw egg whites are high in histamine. Do the yolks have much histamine? I love eggs. For the last 7 mo. I've been on a FODmap diet but it just didnt really solve my diarrhea, etc. So for two days I've been on the anti- histamine diet, feel relief right away. Because everyone has a little different tolerances it seems so confusing, lots of trial and error.

  22. How about waterkefir to improve your gut? I have a hard time with other probiotics, so I want to work up to them by using waterkefir from Mattisson. They are in capsule form, so very small, but it's fermented. Should that be ok if I avoid histamine containing foods? I already take ester C, quercetine complex and scuttelariae to help with histamine. Good video btw!

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